Santhosh Kalash Rajendrakumar

Assistant Professor (Research Focused) @ University of Warwick

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  1. Mohanty A.; Mohapatra A.; Sundaram A.; Sathiyamoorthy P.; Park W.; Rajendrakumar, S. K†; Park, I.-K†. Triple-action cancer therapy using laser-activated NO-releasing metallomicellar nanophotosensitizer for pyroptosis-driven immune reprogramming. Journal of Controlled Release, 2024. https://doi.org/10.1016/j.jconrel.2025.01.012
  2. Concilio, M., Garcia Maset, R., Lemonche, L. P., Kontrimas, V., Song, J.-I., Rajendrakumar, S. K., Harrison, F., Becer, C. R., Perrier, S., Mechanism of Action of Oxazoline-Based Antimicrobial Polymers Against Staphylococcus aureus: In Vivo Antimicrobial Activity Evaluation. Adv. Healthcare Mater. 2023, 2301961. https://doi.org/10.1002/adhm.202301961. 
  3. Dosta, P., Cryer, A.M., Dion, M.Z., Shiraishi, T., Langston, S.P., Lok, D., Wang, J., Harrison, S., Hatten, T., Ganno, M.L., Appleman, V.A., Taboada, G.M., Puigmal, N., Ferber, S., Kalash, S., Prado, M., Rodríguez, A.L., Kamoun, W.S., Abu-Yousif, A.O. & Artzi, N. Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles. Nat. Nanotechnol. 2023. https://doi.org/10.1038/s41565-023-01447-7.
  4. Mohapatra, A.; Mohanty, A.; Sathiyamoorthy, P.; Chahal, S.; Vijayan, V.; Rajendrakumar, S.K.; Park, I.-K. Targeted treatment of gouty arthritis by biomineralized metallic nanozyme-mediated oxidative stress-mitigating nanotherapy. Journal of Materials Chemistry B, 11, 7684-7695, 2023. https://doi:10.1039/D3TB00669G.
  5. Rajendrakumar, S.K., Xu, Q., Khirallah, J. Role of protein corona on nanoparticle-mediated organ and cell-targeted delivery. In Encyclopedia of Nanomaterials (First Edition), Yin, Y., Lu, Y., Xia, Y., Eds.; Elsevier: Oxford, 2023; pp. 506-518.
  6. Mohapatra, A.; Mondal, J.; Sathiyamoorthy, P.; Mohanty, A.; Revuri, V.; Rajendrakumar, S.K.; Lee, Y.K.; Park, I.K. Thermosusceptible Nitric-Oxide-Releasing Nitrogel for Strengthening Antitumor Immune Responses with Tumor Collagen Diminution and Deep Tissue Delivery during NIR Laser-Assisted Photoimmunotherapy. ACS Appl Mater Interfaces 2023, doi:10.1021/acsami.3c01896.
  7. Mohapatra, A.*; Rajendrakumar, S.K.*; Cherukula, K.; Park, M.S.; Padmanaban, S.; Vasukuty, A.; Mohanty, A.; Lee, J.Y.; Bae, W.K.; Park, I.K.; Sugar modified amphiphilic cationic nano-adjuvant ceased tumor immune suppression and rejuvenated peptide vaccine induced antitumor immunity in cervical cancer. RSC Biomaterials Science, 2023.
  8. Mohapatra, A.*; Rajendrakumar, S.K.*; Chandrasekaran, G.; Revuri, V.; Sathiyamoorthy, P.; Lee, Y.K.; Choi, S.Y.; Park, I.K.; Biomineralized Nanoscavenger Abrogates Proinflammatory M1 Macrophage Polarization and Induces Neutrophil Clearance through Reverse Migration During Gouty Arthritis. Applied Mat. And Interfaces, 2023, https://doi.org/10.1021/acsami.2c19684.
  9. Revuri, V.; Mondal, J.; Mohapatra, A.; Rajendrakumar, S.K.; Surwase, S.S.; Park, I.K.; Park, J.; Lee, Y.K.; Catalase-mimicking synthetic nano-enzymes can reduce lipopolysaccharide-induced reactive oxygen generation and promote rapid detection of hydrogen peroxide and L-cysteine. J. Pharm. Investig. 2022, 52, 749–764.
  10. Mathew, A.P.; Rajendrakumar, S.K.*; Mohapatra, A.N.; Vasukutty, A.; Revuri, V.; Mondal, J.; Lee, Y.K.; Lee, J.Y.; Park, I.K.; Hyaluronan-coated Prussian blue nanoparticles relieve LPS-induced peritonitis by suppressing oxidative species generation in tissue-resident macrophages. Biomaterial Science 2021.
  11. Revuri, V.; Rajendrakumar, S.K.*; Park, M.S.; Mohapatra, A.; Uthaman, S.; Mondal, J.; Bae, W.K.; Park, I.K.; Lee, Y.K.; Heat-Confined Tumor-Docking Reversible Thermogel Potentiates Systemic Antitumor Immune Response During Near-Infrared Photothermal Ablation in Triple-Negative Breast Cancer. Adv Healthcare 2021, 10(21): e2100907.
  12. Dosta, , Cryer, A.M., Prado, M., Dion, M.Z., Ferber, S., Kalash, S. and Artzi, N. (2021), Delivery of Stimulator of Interferon Genes (STING) Agonist Using Polypeptide-Modified Dendrimer Nanoparticles in the Treatment of Melanoma. Adv. NanoBiomed Res 2021, 1 (7), 2100006.
  13. Rajendrakumar, S.K.*; Venu, A.; Revuri, V.; Thomas, R.G.; Thirunavukkarasu, G.K.; Jun Zhang, J.; Vijayan, V.; Choi, S-Y.; Lee, J.Y.; Lee, Y-K.; Jeong,Y.Y.; Park, I.K.; Hyaluronic acid Stabilized Redox Sensitive Nano- assembly For Chemo-gene Therapy and T1-T2 MRI Imaging in Drug Resistant Breast Cancer Cells. ACS Mol Pharm 2019, 6,
  14. Rajendrakumar, K.*; Revuri, V.; Samidurai, M.; Mohapatra, A.; Lee, J.H.; Ganesan, P.; Jo, J.; Lee, Y.K.; Park, I.K. ‘Peroxidase’ mimicking nano-assembly mitigates lipopolysaccharide-induced endotoxemia and cognitive damage in the brain by impeding inflammatory signaling in macrophages. Nano Letters 2018.
  15. Rajendrakumar, S.K.; Mohapatra, A.; Singh, B.; Revuri, V.; Lee, Y.-K.; Kim, C.S.; Cho, C.-S.; Park, I.-K. Self- Assembled, Adjuvant/Antigen-Based Nanovaccine Mediates Anti-Tumor Immune Response against Melanoma Polymers 2018, 10, 1063.
  16. Rajendrakumar, K.; Uthaman, S.; Cho, C.S.; Park, I.K. Nanoparticle-based phototriggered cancer immunotherapy and its domino effect in the tumor microenvironment. Biomacromolecules 2018, 19, 1869-1887.
  17. Rajendrakumar, S.K.; Chang, N.C.; Mohapatra, A.; Uthaman, S.; Lee, B.I.; Tsai, W.B.; Park, I.K. A lipophilic ir- 780 dye-encapsulated zwitterionic polymer-lipid micellar nanoparticle for enhanced photothermal therapy and nir- based fluorescence imaging in a cervical tumor mouse Int J Mol Sci 2018, 19.
  18. Rajendrakumar, S.K.; Cherukula, K.; Park, H.J.; Uthaman, S.; Jeong, Y.Y.; Lee, B.I.; Park, I.K. Dual-stimuli- responsive albumin-polyplex nanoassembly for spatially controlled gene release in metastatic breast cancer. J Control Release 2018, 276, 72-83.
  19. Rajendrakumar, S.K.; Uthaman, S.; Cho, C.S.; Park, I.K. Trigger-responsive gene transporters for anticancer Nanomaterials (Basel) 2017, 7.
  20. Rajendrakumar, S.K.; Lakshmanan, V.K, Cho, C.S., Park, I.K., Theranostics. Editor: Ebara, M. Biomaterials 1st edition. ed.; Elsevier: Cambridge, MA, 2016; p 197-215.
  21. Muthiah, M.; Che, H.L.; Kalash, S.; Jo, J.; Choi, S.Y.; Kim, W.J.; Cho, C.S.; Lee, J.Y.; Park, I.K. Formulation of glutathione responsive anti-proliferative nanoparticles from thiolated akt1 sirna and disulfide-crosslinked pei for efficient anti-cancer gene Colloids Surf B Biointerfaces 2015, 126, 322-327.
  22. Nguyen, C.; Muthiah, M.; Islam, M.A.; Kalash, R.S.; Cho, C.S.; Park, H.; Lee, I.K.; Kim, H.J.; Park, I.K.; Cho, K.A. Selective transfection with osmotically active sorbitol modified PEI nanoparticles for enhanced anti-cancer gene therapy. Colloids Surf B Biointerfaces 2014, 119, 126-136.
  23. S Palani, S Raja, R Santhosh Kalash, B Senthil Kumar; Evaluation of nephroprotective and antioxidant activity of Mahonia leschenaultia Takeda on acetaminophen-induced toxicity in rat. Toxicological and Environ Chemistry 2010, 92 (4), 789-799.
  24. K Sakthivel, S Palani, Devi K, Santhosh Kalash, B Senthil Kumar; Phytoconstituents analysis by GC-MS, cardioprotective and antioxidant activity of Buchanania axillaris against Doxorubicin-Induced cardio toxicity in albino rats, International Journal of Pharmaceutical Studies and Research 2010, 1, 34-48.
  25. S Ayyappasamy, R Santhosh Kalash, B Bharathiraja; Enhanced production of cellulase protein on mixture of xylose, lactose, cellulose and sugarcane leaf using Trichoderma reesei 9926a, Advanced Biotech 2009.

*Equally contributed